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Enzyme-triggered CO-releasing molecules (ET-CORMs): Evaluation of biological activity in relation to their structure

Romanski, Steffen, Stamellou, Eleni, Jaraba, J. T., Storz, D., Krämer, B. K., Hafner, M., Amslinger, Sabine, Schmalz, Hans-Günther and Yard, Benito (2013) Enzyme-triggered CO-releasing molecules (ET-CORMs): Evaluation of biological activity in relation to their structure. Free Radic. Biol. Med. 65, pp. 78-88.

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Abstract

Acyloxydiene-Fe(CO)3 complexes act as enzyme-triggered CO-releasing molecules (ET-CORMs) and can deliver CO intracellularly via esterase-mediated hydrolysis. The protective properties of structurally different ET-CORMs on hypothermic preservation damage and their ability to inhibit VCAM-1 expression were tested on cultured human umbilical vein endothelial cells (HUVEC) and renal proximal tubular ...

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Item type:Article
Date:2013
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Dr. Sabine Amslinger
Identification Number:
ValueType
23774042PubMed ID
10.1016/j.freeradbiomed.2013.06.014DOI
Keywords:Adhesion molecules, Carbon monoxide, Endothelial cells, HUVEC, Inflammation, PTEC, human umbilical vein endothelial cells, proximal tubular epithelial cells
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:29292
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