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Enzyme-triggered CO-releasing molecules (ET-CORMs): Evaluation of biological activity in relation to their structure

Romanski, Steffen ; Stamellou, Eleni ; Jaraba, J. T. ; Storz, D. ; Krämer, B. K. ; Hafner, M. ; Amslinger, Sabine ; Schmalz, Hans-Günther ; Yard, Benito



Abstract

Acyloxydiene-Fe(CO)3 complexes act as enzyme-triggered CO-releasing molecules (ET-CORMs) and can deliver CO intracellularly via esterase-mediated hydrolysis. The protective properties of structurally different ET-CORMs on hypothermic preservation damage and their ability to inhibit VCAM-1 expression were tested on cultured human umbilical vein endothelial cells (HUVEC) and renal proximal tubular ...

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