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Pegylated-liposomal doxorubicin and oral topotecan in eight children with relapsed high-grade malignant brain tumors

Wagner, Sabine ; Peters, Ove ; Fels, Christin ; Janssen, Gisela ; Liebeskind, Anne-Kathrin ; Sauerbrey, Axel ; Suttorp, Meinolf ; Hau, Peter ; Wolff, Johannes E. A.


The schedule of PEG-liposomal doxorubicin with 30-40 mg/m(2) every 4 weeks in combination with oral topotecan resulted in tumor response, but the toxicity was high. An individualized increasing dose of PEG-liposomal doxorubicin 10-20 mg/m(2) every two weeks is now recommended.

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