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Pegylated-liposomal doxorubicin and oral topotecan in eight children with relapsed high-grade malignant brain tumors

Wagner, Sabine, Peters, Ove, Fels, Christin, Janssen, Gisela, Liebeskind, Anne-Kathrin, Sauerbrey, Axel, Suttorp, Meinolf, Hau, Peter and Wolff, Johannes E. A. (2008) Pegylated-liposomal doxorubicin and oral topotecan in eight children with relapsed high-grade malignant brain tumors. Journal of neuro-oncology 86 (2), pp. 175-181.

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Abstract

The schedule of PEG-liposomal doxorubicin with 30-40 mg/m(2) every 4 weeks in combination with oral topotecan resulted in tumor response, but the toxicity was high. An individualized increasing dose of PEG-liposomal doxorubicin 10-20 mg/m(2) every two weeks is now recommended.


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Item type:Article
Date:2008
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
17641821PubMed ID
10.1007/s11060-007-9444-xDOI
Classification:
NotationType
Administration, OralMESH
AdolescentMESH
Antineoplastic Combined Chemotherapy Protocols/therapeutic useMESH
Brain Neoplasms/pathologyMESH
Carcinoma/pathologyMESH
ChildMESH
Child, PreschoolMESH
Choroid Plexus Neoplasms/pathologyMESH
Disease-Free SurvivalMESH
Dose-Response Relationship, DrugMESH
Doxorubicin/analogs & derivativesMESH
Drug Administration ScheduleMESH
Drug EruptionsMESH
Glioblastoma/pathologyMESH
Hematologic Diseases/chemically inducedMESH
HumansMESH
Neoplasm Recurrence, Local/drug therapyMESH
Polyethylene Glycols/administration & dosageMESH
RecurrenceMESH
Retrospective StudiesMESH
Stomatitis/chemically inducedMESH
Topotecan/administration & dosageMESH
Treatment OutcomeMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29303
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