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MGMT methylation status: the advent of stratified therapy in glioblastoma?

Hau, Peter ; Stupp, Roger ; Hegi, Monika E.



Abstract

Glioblastomas are the most malignant gliomas with median survival times of only 15 months despite modern therapies. All standard treatments are palliative. Pathogenetic factors are diverse, hence, stratified treatment plans are warranted considering the molecular heterogeneity among these tumors. However, most patients are treated with "one fits all" standard therapies, many of them with minor ...

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