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Low-dose chemotherapy in combination with COX-2 inhibitors and PPAR-gamma agonists in recurrent high-grade gliomas - a phase II study

Hau, Peter, Kunz-Schughart, L., Bogdahn, U., Baumgart, U., Hirschmann, B., Weimann, E., Muhleisen, H., Ruemmele, P., Steinbrecher, A. and Reichle, A. (2007) Low-dose chemotherapy in combination with COX-2 inhibitors and PPAR-gamma agonists in recurrent high-grade gliomas - a phase II study. Oncology 73 (1-2), pp. 21-25.

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Abstract

The study demonstrates that this novel regimen is moderately active and well tolerated in patients with high-grade gliomas. As a comparably small proportion of patients responded, the regimen might only be suitable for a subset of highly selected patients.


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Item type:Article
Date:2007
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
18332649PubMed ID
10.1159/000120028DOI
Classification:
NotationType
AdultMESH
AgedMESH
Antineoplastic Combined Chemotherapy Protocols/therapeutic useMESH
Apoptosis/drug effectsMESH
Brain Neoplasms/pathologyMESH
Cyclooxygenase 2 Inhibitors/therapeutic useMESH
Dacarbazine/analogs & derivativesMESH
Deoxycytidine/analogs & derivativesMESH
Drug Administration ScheduleMESH
Edema/chemically inducedMESH
Efferent Pathways/drug effectsMESH
Erythema/chemically inducedMESH
FemaleMESH
Fluorouracil/analogs & derivativesMESH
Gene Expression Regulation, NeoplasticMESH
Glioblastoma/drug therapyMESH
Glioma/pathologyMESH
HumansMESH
ImmunohistochemistryMESH
Lactones/administration & dosageMESH
MaleMESH
Middle AgedMESH
Neoplasm Recurrence, Local/pathologyMESH
Neovascularization, Pathologic/prevention & controlMESH
PPAR gamma/agonistsMESH
Predictive Value of TestsMESH
Quality of LifeMESH
Sulfones/administration & dosageMESH
Thiazolidinediones/administration & dosageMESH
Treatment OutcomeMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29320
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