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Low-dose chemotherapy in combination with COX-2 inhibitors and PPAR-gamma agonists in recurrent high-grade gliomas - a phase II study

Hau, Peter ; Kunz-Schughart, L. ; Bogdahn, U. ; Baumgart, U. ; Hirschmann, B. ; Weimann, E. ; Muhleisen, H. ; Ruemmele, P. ; Steinbrecher, A. ; Reichle, A.


The study demonstrates that this novel regimen is moderately active and well tolerated in patients with high-grade gliomas. As a comparably small proportion of patients responded, the regimen might only be suitable for a subset of highly selected patients.

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