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Inhibition of TGF-beta2 with AP 12009 in recurrent malignant gliomas: from preclinical to phase I/II studies

Hau, Peter, Jachimczak, Piotr, Schlingensiepen, Reimar, Schulmeyer, Frank, Jauch, Tanya, Steinbrecher, Andreas, Brawanski, Alexander, Proescholdt, Martin A., Schlaier, Jürgen, Buchroithner, Johanna, Pichler, Josef, Wurm, Gabriele, Mehdorn, Maximilian, Strege, Rainer, Schuierer, Gerhard, Villarrubia, Victoria, Fellner, Franz, Jansen, Olav, Straube, Thorsten, Nohria, Virinder, Goldbrunner, Michael, Kunst, Mechthild, Schmaus, Susanne, Stauder, Gerhard, Bogdahn, Ulrich and Schlingensiepen, Karl-Hermann (2007) Inhibition of TGF-beta2 with AP 12009 in recurrent malignant gliomas: from preclinical to phase I/II studies. Oligonucleotides 17 (2), pp. 201-212.

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Abstract

Transforming growth factor-beta2 (TGF-beta2) is known to suppress the immune response to cancer cells and plays a pivotal role in tumor progression by regulating key mechanisms including proliferation, metastasis, and angiogenesis. For targeted protein suppression the TGF-beta2-specific antisense oligodeoxynucleotide AP 12009 was developed. In vitro experiments have been performed to prove ...

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Item type:Article
Date:2007
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
17638524PubMed ID
10.1089/oli.2006.0053DOI
Classification:
NotationType
AdultMESH
Antineoplastic Agents/therapeutic useMESH
Brain Neoplasms/metabolismMESH
Cell Line, TumorMESH
Cell Movement/drug effectsMESH
FemaleMESH
Gene Expression Regulation, Neoplastic/drug effectsMESH
Glioma/metabolismMESH
HumansMESH
MaleMESH
Middle AgedMESH
Oligodeoxyribonucleotides, Antisense/therapeutic useMESH
RecurrenceMESH
Transforming Growth Factor beta2/metabolismMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29329
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