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Inhibition of TGF-beta2 with AP 12009 in recurrent malignant gliomas: from preclinical to phase I/II studies

Hau, Peter ; Jachimczak, Piotr ; Schlingensiepen, Reimar ; Schulmeyer, Frank ; Jauch, Tanya ; Steinbrecher, Andreas ; Brawanski, Alexander ; Proescholdt, Martin A. ; Schlaier, Jürgen ; Buchroithner, Johanna ; Pichler, Josef ; Wurm, Gabriele ; Mehdorn, Maximilian ; Strege, Rainer ; Schuierer, Gerhard ; Villarrubia, Victoria ; Fellner, Franz ; Jansen, Olav ; Straube, Thorsten ; Nohria, Virinder ; Goldbrunner, Michael ; Kunst, Mechthild ; Schmaus, Susanne ; Stauder, Gerhard ; Bogdahn, Ulrich ; Schlingensiepen, Karl-Hermann



Abstract

Transforming growth factor-beta2 (TGF-beta2) is known to suppress the immune response to cancer cells and plays a pivotal role in tumor progression by regulating key mechanisms including proliferation, metastasis, and angiogenesis. For targeted protein suppression the TGF-beta2-specific antisense oligodeoxynucleotide AP 12009 was developed. In vitro experiments have been performed to prove ...

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