| Item type: | Article | ||||||||||||||||||||||||||||||
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| Journal or Publication Title: | Oligonucleotides | ||||||||||||||||||||||||||||||
| Publisher: | MARY ANN LIEBERT, INC | ||||||||||||||||||||||||||||||
| Place of Publication: | NEW ROCHELLE | ||||||||||||||||||||||||||||||
| Volume: | 17 | ||||||||||||||||||||||||||||||
| Number of Issue or Book Chapter: | 2 | ||||||||||||||||||||||||||||||
| Page Range: | pp. 201-212 | ||||||||||||||||||||||||||||||
| Date: | 2007 | ||||||||||||||||||||||||||||||
| Institutions: | Medicine > Lehrstuhl für Neurochirurgie Medicine > Lehrstuhl für Neurologie Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT) | ||||||||||||||||||||||||||||||
| Identification Number: |
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| Classification: |
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| Keywords: | GROWTH-FACTOR-BETA; TUMOR-INDUCED IMMUNOSUPPRESSION; TGF-BETA; BRAIN-TUMORS; ANTISENSE OLIGONUCLEOTIDES; GLIOBLASTOMA; CANCER; CELLS; TEMOZOLOMIDE; EXPRESSION; | ||||||||||||||||||||||||||||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||||||||||||||||||||||||||||
| Status: | Published | ||||||||||||||||||||||||||||||
| Refereed: | Yes, this version has been refereed | ||||||||||||||||||||||||||||||
| Created at the University of Regensburg: | Unknown | ||||||||||||||||||||||||||||||
| Item ID: | 29329 |
Web of ScienceAbstract
Transforming growth factor-beta2 (TGF-beta 2) is known to suppress the immune response to cancer cells and plays a pivotal role in tumor progression by regulating key mechanisms including proliferation, metastasis, and angiogenesis. For targeted protein suppression the TGF-beta 2-specific antisense oligodeoxynucleotide AP 12009 was developed. In vitro experiments have been performed to prove ...
Abstract
Transforming growth factor-beta2 (TGF-beta 2) is known to suppress the immune response to cancer cells and plays a pivotal role in tumor progression by regulating key mechanisms including proliferation, metastasis, and angiogenesis. For targeted protein suppression the TGF-beta 2-specific antisense oligodeoxynucleotide AP 12009 was developed. In vitro experiments have been performed to prove specificity and efficacy of the TGF-beta 2 inhibitor AP 12009 employing patient-derived malignant glioma cells as well as peripheral blood mononuclear cells (PBMCs) from patients. Clinically, the antisense compound AP 12009 was assessed in three Phase I/II-studies for the treatment of patients with recurrent or refractory malignant (high-grade) glioma WHO grade III or IV. Although the study was not primarily designed as an efficacy evaluation, prolonged survival compared to literature data and response data were observed, which are very rarely seen in this tumor indication. Two patients experienced long-lasting complete tumor remissions. These results implicate targeted TGF-beta 2-suppression using AP 12009 as a promising novel approach for malignant gliomas and other highly aggressive, TGF-beta 2-overexpressing tumors.
Metadata last modified: 29 Sep 2021 07:39
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