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CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles

Beier, Dagmar, Hau, Peter, Proescholdt, Martin A., Lohmeier, Annette, Wischhusen, Jörg, Oefner, Peter J., Aigner, Ludwig, Brawanski, Alexander, Bogdahn, Ulrich and Beier, Christoph P. (2007) CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles. Cancer research 67 (9), pp. 4010-4015.

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Abstract

Although glioblastomas show the same histologic phenotype, biological hallmarks such as growth and differentiation properties vary considerably between individual cases. To investigate whether different subtypes of glioblastomas might originate from different cells of origin, we cultured tumor cells from 22 glioblastomas under medium conditions favoring the growth of neural and cancer stem cells ...

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Item type:Article
Date:2007
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
17483311PubMed ID
10.1158/0008-5472.CAN-06-4180DOI
Classification:
NotationType
AnimalsMESH
Antigens, CD/geneticsMESH
Brain Neoplasms/pathologyMESH
Cell Growth Processes/physiologyMESH
Flow CytometryMESH
Gene Expression ProfilingMESH
Glioblastoma/pathologyMESH
Glycoproteins/geneticsMESH
HumansMESH
MiceMESH
Mice, NudeMESH
Neoplastic Stem Cells/physiologyMESH
Peptides/geneticsMESH
Tumor Cells, CulturedMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29330
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