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CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles

Beier, Dagmar ; Hau, Peter ; Proescholdt, Martin A. ; Lohmeier, Annette ; Wischhusen, Jörg ; Oefner, Peter J. ; Aigner, Ludwig ; Brawanski, Alexander ; Bogdahn, Ulrich ; Beier, Christoph P.



Abstract

Although glioblastomas show the same histologic phenotype, biological hallmarks such as growth and differentiation properties vary considerably between individual cases. To investigate whether different subtypes of glioblastomas might originate from different cells of origin, we cultured tumor cells from 22 glioblastomas under medium conditions favoring the growth of neural and cancer stem cells ...

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