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The role of versican isoforms V0/V1 in glioma migration mediated by transforming growth factor-beta2

Arslan, F. ; Bosserhoff, A.-K. ; Nickl-Jockschat, T. ; Doerfelt, A. ; Bogdahn, U. ; Hau, Peter



Abstract

Versican is a large chondroitin sulphate proteoglycan produced by several tumour cell types, including high-grade glioma. The increased expression of certain versican isoforms in the extracellular matrix (ECM) plays a role in tumour cell growth, adhesion and migration. Transforming growth factor-beta2 (TGF-beta2) is an important modulator of glioma invasion, partially by remodeling the ECM. ...

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