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Safety and feasibility of long-term temozolomide treatment in patients with high-grade glioma

Hau, Peter, Koch, D., Hundsberger, T., Marg, E., Bauer, B., Rudolph, R., Rauch, M., Brenner, A., Rieckmann, P., Schuth, J., Jauch, T., Koch, H. and Bogdahn, U. (2007) Safety and feasibility of long-term temozolomide treatment in patients with high-grade glioma. Neurology 68 (9), pp. 688-690.

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Abstract

We surveyed neuro-oncologists regarding patients treated with temozolomide for at least 12 cycles or 12 months. Patients receiving first-line temozolomide for a median 13 cycles had a median progression-free survival (PFS) of 14 months. Patients with recurrent disease receiving a median 14 cycles had a median PFS of 15.5 months. A small percentage of patients experienced grade III to IV toxicity. These results suggest that long-term treatment with temozolomide is feasible and well tolerated.


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Item type:Article
Date:2007
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
17325277PubMed ID
10.1212/01.wnl.0000255937.27012.eeDOI
Classification:
NotationType
AdolescentMESH
AdultMESH
AgedMESH
Antineoplastic Agents, Alkylating/administration & dosageMESH
Brain Neoplasms/mortalityMESH
Dacarbazine/analogs & derivativesMESH
Disease-Free SurvivalMESH
Feasibility StudiesMESH
FemaleMESH
Glioma/mortalityMESH
HumansMESH
Longitudinal StudiesMESH
MaleMESH
Middle AgedMESH
Risk Assessment/methodsMESH
Risk FactorsMESH
Survival AnalysisMESH
Survival RateMESH
Treatment OutcomeMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29332
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