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An imbalance between Smad and MAPK pathways is responsible for TGF-beta tumor promoting effects in high-grade gliomas

Nickl-Jockschat, T., Arslan, F., Doerfelt, A., Bogdahn, U., Bosserhoff, A. and Hau, Peter (2007) An imbalance between Smad and MAPK pathways is responsible for TGF-beta tumor promoting effects in high-grade gliomas. International journal of oncology 30 (2), pp. 499-507.

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Date of publication of this fulltext: 17 Jan 2014 08:46

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Abstract

The transforming growth factor-beta (TGF-beta) plays a pivotal role in the pathobiology of human gliomas: during carcinogenesis, it turns from a tumor suppressor to a tumor promoter. The traditional Smad pathway and the more recently discovered MAPK pathway are the most important pathways for TGF-beta related intracellular signal transduction mediating differential pathobiological effects. In ...

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Item type:Article
Date:2007
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
17203233PubMed ID
Classification:
NotationType
Brain Neoplasms/metabolismMESH
Cell Line, TumorMESH
Cell MovementMESH
Cell ProliferationMESH
Extracellular Signal-Regulated MAP Kinases/metabolismMESH
Gene Expression Regulation, NeoplasticMESH
Glioma/metabolismMESH
HumansMESH
MAP Kinase Signaling SystemMESH
Models, BiologicalMESH
Oligonucleotides/metabolismMESH
PhosphorylationMESH
Promoter Regions, GeneticMESH
Signal TransductionMESH
Smad Proteins/metabolismMESH
Transforming Growth Factor beta/biosynthesisMESH
Transforming Growth Factor beta2/metabolismMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29333
Owner only: item control page

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