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An imbalance between Smad and MAPK pathways is responsible for TGF-beta tumor promoting effects in high-grade gliomas

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Nickl-Jockschat, T. ; Arslan, F. ; Doerfelt, A. ; Bogdahn, U. ; Bosserhoff, A. ; Hau, Peter
Date of publication of this fulltext: 17 Jan 2014 08:46


The transforming growth factor-beta (TGF-beta) plays a pivotal role in the pathobiology of human gliomas: during carcinogenesis, it turns from a tumor suppressor to a tumor promoter. The traditional Smad pathway and the more recently discovered MAPK pathway are the most important pathways for TGF-beta related intracellular signal transduction mediating differential pathobiological effects. In ...


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