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Inhibition of immunosuppressive effects of melanoma-inhibiting activity (MIA) by antisense techniques

Jachimczak, Piotr, Apfel, Rainer, Bosserhoff, Anja-Katrin, Fabel, Klaus, Hau, Peter, Tschertner, Ines, Wise, Petra, Schlingensiepen, Karl-Hermann, Schuler-Thurner, Beatrix and Bogdahn, Ulrich (2005) Inhibition of immunosuppressive effects of melanoma-inhibiting activity (MIA) by antisense techniques. International journal of cancer. Journal international du cancer 113 (1), pp. 88-92.

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Abstract

Melanoma inhibitory activity (MIA) is an 11 kD protein secreted by malignant melanomas. Recent studies revealed an interaction of MIA with epitopes of extracellular matrix proteins including fibronectin. Structural homology of MIA with the binding sites of alpha4beta1 integrin results in complex interactions of MIA with molecules binding to alpha4beta1 integrin. As cells of the immune system ...

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Item type:Article
Date:2005
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
15386421PubMed ID
10.1002/ijc.20549DOI
Classification:
NotationType
Cell Line, TumorMESH
Cytotoxicity, ImmunologicMESH
Extracellular Matrix ProteinsMESH
Gene Expression Regulation, NeoplasticMESH
Glioma/metabolismMESH
HumansMESH
Interleukin-2/metabolismMESH
Killer Cells, Lymphokine-Activated/immunologyMESH
Leukocytes, Mononuclear/immunologyMESH
Lymphocyte ActivationMESH
Melanoma/metabolismMESH
Neoplasm ProteinsMESH
Oligonucleotides, Antisense/metabolismMESH
Phosphates/metabolismMESH
Proteins/immunologyMESH
Recombinant Proteins/immunologyMESH
ThionucleotidesMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29341
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