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Inhibition of immunosuppressive effects of melanoma-inhibiting activity (MIA) by antisense techniques

Jachimczak, Piotr ; Apfel, Rainer ; Bosserhoff, Anja-Katrin ; Fabel, Klaus ; Hau, Peter ; Tschertner, Ines ; Wise, Petra ; Schlingensiepen, Karl-Hermann ; Schuler-Thurner, Beatrix ; Bogdahn, Ulrich



Abstract

Melanoma inhibitory activity (MIA) is an 11 kD protein secreted by malignant melanomas. Recent studies revealed an interaction of MIA with epitopes of extracellular matrix proteins including fibronectin. Structural homology of MIA with the binding sites of alpha4beta1 integrin results in complex interactions of MIA with molecules binding to alpha4beta1 integrin. As cells of the immune system ...

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