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Maintenance therapy with 13-cis retinoid acid in high-grade glioma at complete response after first-line multimodal therapy--a phase-II study

Wismeth, Caecilia ; Hau, Peter ; Fabel, Klaus ; Baumgart, Ulrike ; Hirschmann, Birgit ; Koch, Horst ; Jauch, Tanja ; Grauer, Oliver ; Drechsel, Lisa ; Brawanski, Alexander ; Bogdahn, Ulrich ; Steinbrecher, Andreas


There is an urgent need for strategies maintaining remission in patients with malignant glioma. Maintenance therapy with high-dose cRA is feasible and well tolerated over long periods of time. A controlled clinical trial to test the efficacy of cRA as a maintenance treatment in malignant glioma is warranted.

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