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Pegylated liposomal doxorubicin-efficacy in patients with recurrent high-grade glioma

Hau, Peter ; Fabel, Klaus ; Baumgart, Ulrike ; Rümmele, Petra ; Grauer, Oliver ; Bock, Annekatrin ; Dietmaier, Christopher ; Dietmaier, Wolfgang ; Dietrich, Jörg ; Dudel, Christine ; Hübner, Franz ; Jauch, Tanya ; Drechsel, Elisabeth ; Kleiter, Ingo ; Wismeth, Cäcile ; Zellner, Anton ; Brawanski, Alexander ; Steinbrecher, Andreas ; Marienhagen, Jörg ; Bogdahn, Ulrich


Pegylated liposomal doxorubicin administered alone or in combination with tamoxifen is safe and moderately effective in patients with recurrent high-grade glioma. None of the putative predictors for response that were evaluated proved to be significant in this setting.

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