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Opening or Closing the Lock? - When Reactivity is the Key to Biological Activity.

Al-Rifai, Nafisah ; Rücker, Hannelore ; Amslinger, Sabine


Thiol-mediated processes play a key role to induce or inhibit inflammation proteins. Tailoring the reactivity of electrophiles can enhance the selectivity to address only certain surface cysteines. Fourteen 2′,3,4,4′-tetramethoxychalcones with different α-X substituents (X=H, F, Cl, Br, I, CN, Me, p-NO2-C6H4, Ph, p-OMe-C6H4, NO2, CF3, COOEt, COOH) were synthesized, containing the potentially ...


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