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Transforming growth factor-beta-mediated regulation of human peripheral blood mononuclear cell proliferation as detected with phosphorothioate antisense oligodeoxynucleotides

Jachimczak, P., Fabel-Schulte, K., Hessdörfer, B., Brysch, W., Schlingensiepen, K. H., Blesch, A. and Bogdahn, U. (1995) Transforming growth factor-beta-mediated regulation of human peripheral blood mononuclear cell proliferation as detected with phosphorothioate antisense oligodeoxynucleotides. Cellular immunology 165 (1), pp. 125-133.

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Abstract

Transforming growth factor-beta (TGF-beta) is a potent cytokine that has influence upon immunosuppressive as well as proinflammatory processes. In this context we have investigated the role of endogenous TGF-beta in human peripheral blood mononuclear cells (PBMCs) by TGF-beta 1 phosphorothioate antisense oligodeoxynucleotides (TGF-beta 1-S-ODNs). In short-term cultures (up to 3 days), TGF-beta ...

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Item type:Article
Date:1995
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
7671316PubMed ID
Classification:
NotationType
Base SequenceMESH
Cell Division/drug effectsMESH
Cells, CulturedMESH
HumansMESH
Leukocytes, Mononuclear/cytologyMESH
Molecular Sequence DataMESH
Oligonucleotides, Antisense/pharmacologyMESH
RNA, Messenger/analysisMESH
Thionucleotides/pharmacologyMESH
Time FactorsMESH
Transforming Growth Factor beta/pharmacologyMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29377
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