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Autoinduction of platelet derived growth factor (PDGF) A-chain mRNA expression in a human malignant melanoma cell line and growth inhibitory effects of PDGF-A-chain mRNA-specific antisense molecules

Behl, C., Bogdahn, U., Winkler, J., Apfel, R., Brysch, W. and Schlingensiepen, K. H. (1993) Autoinduction of platelet derived growth factor (PDGF) A-chain mRNA expression in a human malignant melanoma cell line and growth inhibitory effects of PDGF-A-chain mRNA-specific antisense molecules. Biochemical and biophysical research communications 193 (2), pp. 744-751.

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Abstract

Autoinduction of PDGF-A-chain mRNA's was demonstrated in cells of a human malignant melanoma cell line (HTZ 19), indicating a PDGF-induced amplification of an autocrine growth factor loop mechanism. PDGF-alpha receptors were detected by immunocytochemistry in HTZ 19 melanoma cells. Exogenously administered PDGF-AA exerted an increase in cell proliferation by 70% at 200 ng/ml PDGF in ...

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Item type:Article
Date:1993
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
8512572PubMed ID
10.1006/bbrc.1993.1688DOI
Classification:
NotationType
Base SequenceMESH
Cell Division/drug effectsMESH
Gene Expression/drug effectsMESH
HumansMESH
Macromolecular SubstancesMESH
MelanomaMESH
Molecular Sequence DataMESH
Oligonucleotides, Antisense/pharmacologyMESH
Platelet-Derived Growth Factor/pharmacologyMESH
RNA, Antisense/pharmacologyMESH
RNA, Messenger/metabolismMESH
RNA, Neoplasm/metabolismMESH
Receptors, Platelet-Derived Growth Factor/metabolismMESH
Thionucleotides/pharmacologyMESH
Tumor Cells, CulturedMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29385
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