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In vitro studies on drug interaction of ifosfamide and ACNU in primary and metastatic human brain tumours

Bogdahn, U. ; Drenkard, D. ; Lutz, M. ; Apfel, R. ; Behl, C.


Combination chemotherapy is widely employed in clinical oncology; however, there is no generally accepted model to evaluate individual tumour susceptibility to a given drug combination protocol. We therefore investigated the drug interaction of ifosfamide (4-hydroxyperoxy-ifosfamide) and ACNU in a recently developed in vitro model of paired sequential combination chemotherapy in primary and ...


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