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Therapy of malignant brain tumors: comparison of the in vitro activities of vidarabin-monophosphate, BCNU and 5-fluorouracil

Bogdahn, U., Weber, H., Zapf, J., Dünisch, G., Löbering, H. G. and Mertens, H. G. (1987) Therapy of malignant brain tumors: comparison of the in vitro activities of vidarabin-monophosphate, BCNU and 5-fluorouracil. Acta neurologica Scandinavica 75 (1), pp. 28-36.

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Abstract

BCNU (carmustine), 5-Fluorouracil (5-FU) and Vidarabin-monophosphate (ARA-A5'P) were compared in their activities against 30 cell lines of primary (n = 21) and metastatic (n = 9) brain tumors, which were characterized in tissue culture by cytochemical, immunological and cytogenetic criteria. In vivo achievable concentration-time products were correlated with in vitro pharmacokinetic data. A micro ...

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Item type:Article
Date:1987
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
3577665PubMed ID
Classification:
NotationType
Brain Neoplasms/secondaryMESH
Carmustine/therapeutic useMESH
Cell LineMESH
Dose-Response Relationship, DrugMESH
Fluorouracil/therapeutic useMESH
HumansMESH
KineticsMESH
Vidarabine/therapeutic useMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29394
Owner only: item control page
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