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A single-arm phase II Austrian/German multicenter trial on continuous daily sunitinib in primary glioblastoma at first recurrence (SURGE 01-07)

Hutterer, Markus ; Nowosielski, Martha ; Haybaeck, Johannes ; Embacher, Sabine ; Stockhammer, Florian ; Gotwald, Thaddäus ; Holzner, Bernhard ; Capper, David ; Preusser, Matthias ; Marosi, Christine ; Oberndorfer, Stefan ; Moik, Martin ; Buchroithner, Johanna ; Seiz, Marcel ; Tuettenberg, Jochen ; Herrlinger, Ulrich ; Wick, Antje ; Vajkoczy, Peter ; Stockhammer, Günther



Abstract

Background: Due to the redundancy of molecular pathways simultaneously involved in glioblastoma growth and angiogenesis, therapeutic approaches intervening at multiple levels seem particularly appealing. Methods: This prospective, multicenter, single-arm phase II trial was designed to evaluate the antitumor activity of sunitinib, an oral small-molecule inhibitor of several receptor tyrosine ...

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