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Pharmacokinetics of a Self-Microemulsifying Drug Delivery System of Tacrolimus

von Süßkind-Schwendi, Marietta ; Gruber, Michael ; Touraud, Didier ; Kunz, Werner ; Schmid, Christof ; Hirt, Stephan ; Lehle, Karla


This study evaluated the pharmacokinetics of tacrolimus (Tac) in a novel self-microemulsifying drug delivery system (SMEDDS) for improved oral administration. SMEDDS Tac consisted of Et oleate as the oily phase, Solutol HS 15 as the surfactant and glycofurol as the co-surfactant and contained 0.5 mg/mL tacrolimus. Blood and tissue concns. of tacrolimus from two study groups (oral application of ...


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