Chromatin-Specific Regulation of Mammalian rDNA Transcription by Clustered TTF-I Binding Sites

URN to cite this document:: urn:nbn:de:bvb:355-epub-295153
DOI to cite this document:: 10.5283/epub.29515

Diermeier, Sarah ; Nemmeth, Attila ; Rehli, Michael ; Grummt, Ingrid ; Längst, Gernot

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Date of publication of this fulltext: 12 Feb 2014 11:28

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Abstract

Enhancers and promoters often contain multiple binding sites for the same transcription factor, suggesting that homotypic clustering of binding sites may serve a role in transcription regulation. Here we show that clustering of binding sites for the transcription termination factor TTF-I downstream of the pre-rRNA coding region specifies transcription termination, increases the efficiency of ...