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New aspects of an old drug: Diclofenac targets MYC and glucose metabolism in tumor cells

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Kreutz, Marina ; Gottfried, Eva ; Lang, Sven A. ; Renner, Kathrin ; Bosserhoff, Anja-Katrin ; Gronwald, Wolfram ; Rehli, Michael ; Einhell, Sabine ; Gedig, Isabel ; Singer, Katrin ; Seilbeck, Anton ; Mackensen, Andreas ; Grauer, Oliver ; Hau, Peter ; Dettmer, Katja ; Andreesen, Reinhard ; Oefner, Peter
License: Creative Commons: Attribution 3.0
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Date of publication of this fulltext: 12 Feb 2014 13:05


Non-steroidal anti-inflammatory drugs such as diclofenac exhibit potent anticancer effects. Up to now these effects were mainly attributed to its classical role as COX-inhibitor. Here we show novel COX-independent effects of diclofenac. Diclofenac significantly diminished MYC expression and modulated glucose metabolism resulting in impaired melanoma, leukemia, and carcinoma cell line ...


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