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New aspects of an old drug: Diclofenac targets MYC and glucose metabolism in tumor cells

Kreutz, Marina, Gottfried, Eva, Lang, Sven A., Renner, Kathrin, Bosserhoff, Anja-Katrin, Gronwald, Wolfram, Rehli, Michael, Einhell, Sabine, Gedig, Isabell, Singer, Katrin, Seilbeck, Anton, Mackensen, Andreas, Grauer, Oliver, Hau, Peter, Dettmer, Katja, Andreesen, Reinhard and Oefner, Peter (2013) New aspects of an old drug: Diclofenac targets MYC and glucose metabolism in tumor cells. PLoS ONE 8 (7), e66987.

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Date of publication of this fulltext: 12 Feb 2014 13:05

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Abstract

Non-steroidal anti-inflammatory drugs such as diclofenac exhibit potent anticancer effects. Up to now these effects were mainly attributed to its classical role as COX-inhibitor. Here we show novel COX-independent effects of diclofenac. Diclofenac significantly diminished MYC expression and modulated glucose metabolism resulting in impaired melanoma, leukemia, and carcinoma cell line ...

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Item type:Article
Date:9 July 2013
Institutions:Medicine > Lehrstuhl für Chirurgie
Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Medicine > Lehrstuhl für Neurologie
Medicine > Lehrstuhl für Pathologie
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1371/journal.pone.0066987DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:29545
Owner only: item control page

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