No high level evidence to support the use of oral H1 antihistamines as monotherapy for eczema: a summary of a Cochrane systematic review

URN to cite this document:

urn:nbn:de:bvb:355-epub-296265 Copy

DOI to cite this document:

10.5283/epub.29626 Copy

Zuuren, Esther J. van ; Apfelbacher, Christian J. ; Fedorowicz, Zbys ; Jupiter, Aldrin ; Matterne, Uwe ; Weisshaar, Elke

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Date of publication of this fulltext: 19 Mar 2014 13:17

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Details

Item type:	Article
Journal or Publication Title:	Systematic Reviews
Publisher:	BioMed Central
Volume:	3
Number of Issue or Book Chapter:	25
Date:	13 March 2014
Institutions:	Medicine > Institut für Epidemiologie und Präventivmedizin
Projects:	Open Access Publizieren (DFG)
Identification Number:	Value Type 10.1186/2046-4053-3-25 DOI
Keywords:	Cochrane review; eczema; H1 antihistamines; evidence based medicine
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	29626

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Abstract

Background The most important symptom as well as one of the major diagnostic criteria for eczema is itch. Although oral antihistamines continue to be prescribed for people with eczema, it is unclear if they are effective and safe in relieving itch and skin lesions. We sought to evaluate the available evidence on effectiveness of oral antihistamines (H1 antagonists) as monotherapy in children and ...

Abstract

Background

The most important symptom as well as one of the major diagnostic criteria for eczema is itch. Although oral antihistamines continue to be prescribed for people with eczema, it is unclear if they are effective and safe in relieving itch and skin lesions. We sought to evaluate the available evidence on effectiveness of oral antihistamines (H1 antagonists) as monotherapy in children and adults with eczema.
Methods

Searches included 10 databases and trial registers as well as conference proceedings (January 2014). Randomised controlled trials that assessed the effects of oral H1 antihistamines as monotherapy in children and adults with eczema were included.
Results

Our searches retrieved 757 references, but no randomised controlled trial met our inclusion criteria. Most studies allowed concomitant treatments, making the assessment of the individual effects of oral H1 antihistamines impossible.
Conclusions

There is currently no high-level evidence to support or refute the efficacy or safety of oral H1 antihistamines used as monotherapy for eczema. A further review of studies that assesses the effects of oral H1 antihistamines as ‘add-on’ therapy together with concomitant treatments is warranted to determine the beneficial effects of this group of medications in the treatment of eczema.

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Metadata last modified: 26 Nov 2020 01:20

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