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The alpha-substitution of chalcones as a tool to modulate the reactivity and biological activity

Al-Rifai, Nafisah (2014) The alpha-substitution of chalcones as a tool to modulate the reactivity and biological activity. PhD, Universität Regensburg.

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Date of publication of this fulltext: 27 Mar 2014 14:35

Abstract (English)

The chalcone motif can be a privileged structure in drug design if the reactivity is modulated to reach a suitable range. Chalcones are relatively easily synthesized and they have a structural versatility that can affect their reactivity as Michael acceptors. Since the reactivity of chalcones as Michael acceptors is essential for their biological activity, the assessment of this reactivity is of ...

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Translation of the abstract (German)

Chalkone können als vielversprechende Strukturen für die Arzneimittelforschung betrachtet werden, wenn sich deren Reaktivitäten in einem bestimmten Rahmen befinden. Sie können relativ leicht synthetisiert werden. Aufgrund ihrer strukturellen Vielfalt ist eine Beeinflussung ihrer Michael-Akzeptor-Aktivität möglich. Da die Reaktivität der Chalkone als Michael-Akzeptoren essentiell für ihre ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:27 March 2014
Referee:PD Dr. Sabine Amslinger
Date of exam:13 March 2014
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Dr. Sabine Amslinger
Keywords:chalcones, alpha-substitution, Michael-acceptors
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:29627
Owner only: item control page

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