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Vascular endothelial growth factor (VEGF) modulates vascular permeability and inflammation in rat brain

Proescholdt, M. A. ; Heiss, J. D. ; Walbridge, S. ; Mühlhauser, J. ; Capogrossi, M. C. ; Oldfield, E. H. ; Merrill, M. J.


Abstract

Vascular endothelial growth factor (VEGF) is an angiogenic growth factor that also induces vascular permeability and macrophage migration. VEGF expression is weak in normal adult brain, but is strongly upregulated in glioma cells and reactive astrocytes, suggesting that chronic overexpression of VEGF in the brain contributes to blood-brain barrier (BBB) breakdown. We examined the effects of ...

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