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Cleavable carbamate linkers for controlled protein delivery from hydrogels

Hammer, Nadine, Brandl, Ferdinand, Kirchhof, Susanne and Goepferich, Achim (2014) Cleavable carbamate linkers for controlled protein delivery from hydrogels. Journal of Controlled Release 183, pp. 67-76.

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Abstract

The reversible attachment of proteins to polymers is one potential strategy to control protein release from hydrogels. In this study, we report the reversible attachment of lysozyme to poly(ethylene glycol) (PEG) by degradable carbamate linkers. Phenyl groups with different substituents were used to control the rate of carbamate hydrolysis and the resulting protein release. Sodium dodecyl sulfate ...

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Item type:Article
Date:2014
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)
Identification Number:
ValueType
10.1016/j.jconrel.2014.03.031DOI
Keywords:Poly(ethylene glycol); Hydrogel; Protein tethering; Cleavable linker; Reversible PEGylation; Release
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:29807
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