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Synthesis and structure-activity relationships of inhibitors of bacterial hyaluronidase: An approach to obtain compounds with drug-like properties

URN to cite this document:
urn:nbn:de:bvb:355-epub-298551
Meyer, Carolin
Date of publication of this fulltext: 29 Apr 2014 16:15


Abstract (English)

Hyaluronidases are enzymes that predominantly degrade hyaluronan, a major constituent of the extracellular matrix. They can be ubiquitously found throughout the animal kingdom and have been isolated from a large number of different organs and animal venoms. Additionally, hyaluronidases are produced by bacteria and fungi. In case of pathogenic bacteria and animal venoms, the hyaluronidases act as ...

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Translation of the abstract (German)

Hyaluronidasen sind Enzyme, die Hyaluronsäure, einen Hauptbestandteil der extrazellulären Matrix, abbauen. Sie kommen ubiquitär im gesamten Tierreich vor und konnten aus einer Reihe verschiedener Organe und aus Tiergiften isoliert werden. Des Weiteren werden Hyaluronidasen von Bakterien und Pilzen produziert. Die Hyaluronidasen aus Tiergiften (z.B. Schlangen- oder Bienengift) und aus pathogenen ...

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