Pauly, Diana, Nagel, Benedik M., Reinders, Jörg 
, Kilian, Tobias, Wulf, Matthias, Ackermann, Susanne, Ehrenstein, Boris, Zipfel, Peter F., Skerka, Christine and Weber, Bernhard H. F.
(2014)
A Novel Antibody against Human Properdin Inhibits the Alternative Complement System and Specifically Detects Properdin from Blood Samples.
PLos ONE 9 (5), e96371.
| License: Creative Commons Attribution 3.0 PDF - Published Version Download (2MB) |
Other URL: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0096371
Abstract
The complement system is an essential part of the innate immune system by acting as a first line of defense which is stabilized by properdin, the sole known positive regulator of the alternative complement pathway. Dysregulation of complement can promote a diversity of human inflammatory diseases which are treated by complement inhibitors. Here, we generated a novel blocking monoclonal antibody ...
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| Item type: | Article | ||||
|---|---|---|---|---|---|
| Date: | 5 May 2014 | ||||
| Institutions: | Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner) Medicine > Lehrstuhl für Humangenetik | ||||
| Projects: | Open Access Publizieren (DFG) | ||||
| Identification Number: |
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| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 29962 |
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