A Novel Antibody against Human Properdin Inhibits the Alternative Complement System and Specifically Detects Properdin from Blood Samples

URN to cite this document:: urn:nbn:de:bvb:355-epub-299626
DOI to cite this document:: 10.5283/epub.29962

Pauly, Diana ; Nagel, Benedikt M. ; Reinders, Jörg ; Killian, Tobias ; Wulf, Matthias ; Ackermann, Susanne

; Ehrenstein, Boris ; Zipfel, Peter F. ; Skerka, Christine ; Weber, Bernhard H. F.

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Date of publication of this fulltext: 19 May 2014 07:51

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Abstract

The complement system is an essential part of the innate immune system by acting as a first line of defense which is stabilized by properdin, the sole known positive regulator of the alternative complement pathway. Dysregulation of complement can promote a diversity of human inflammatory diseases which are treated by complement inhibitors. Here, we generated a novel blocking monoclonal antibody ...