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Synthesis of Phenyl-1-benzoxepinols Isolated from Butcher’s Broom and Analogous Benzoxepines

Herrmann, Josef M. ; Untergehrer, Monika ; Jürgenliemk, Guido ; Heilmann, Jörg ; König, Burkhard


Extracts of Ruscus aculeatus L., known as butcher's broom, are mainly used for the treatment of chronic venous insufficiency (CVI). In a recent study on the phenolic compounds of Rusci rhizoma, new phenyl-1-benzoxepinols were isolated. As the therapeutic effect of butcher's broom is ascribed to the pharmacological activity of the main constituents, steroidal saponins and their aglycones the ...


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