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A CD3-Specific Antibody Reduces Cytokine Production and Alters Phosphoprotein Profiles in Intestinal Tissues From Patients With Inflammatory Bowel Disease

Vossenkämper, Anna ; Hundsrucker, Christian ; Page, Kevin ; van Maurik, Andre ; Sanders, Theodore J. ; Stagg, Andrew J. ; Das, Lisa ; MacDonald, Thomas T.


Background & Aims T cells mediate the development of inflammation in inflammatory bowel disease (IBD). We investigated the effects of an antibody against CD3 called otelixizumab, which induces immune tolerance, in intestinal mucosa samples from patients. Methods Intestinal tissues were isolated from patients undergoing routine endoscopy or from patients undergoing intestinal surgery for colon ...


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