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CLL-cells induce IDOhi CD14+HLA-DRlo myeloid derived suppressor cells that inhibit T-cell responses and promote TRegs

Jitschin, Regina, Braun, Martina, Büttner, Maike, Dettmer, Katja, Bricks, Juliane, Berger, Jana, Eckart, Michael J., Krause, Stefan W, Oefner, Peter, Le Blanc, Katarina, Mackensen, Andreas and Mougiakakos, Dimitrios (2014) CLL-cells induce IDOhi CD14+HLA-DRlo myeloid derived suppressor cells that inhibit T-cell responses and promote TRegs. Blood.

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Other URL: http://www.bloodjournal.org/content/early/2014/05/21/blood-2013-12-546416.long?sso-checked=1


Abstract

Myeloid derived suppressor cells (MDSCs) represent a heterogeneous population that shares certain characteristics including an aberrant myeloid phenotype and the ability to suppress T-cells. MDSCs have been predominantly studied in malignant diseases and findings suggest involvement in tumor-associated immune suppression. Chronic lymphocytic leukemia (CLL) is the leukemia with the highest ...

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Item type:Article
Date:May 2014
Additional Information (public):Blood First Edition Paper, prepublished online May 21, 2014
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
24850760PubMed ID
/10.1182/blood-2013-12-546416DOI
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:30487
Owner only: item control page
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