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CLL-cells induce IDOhi CD14+HLA-DRlo myeloid derived suppressor cells that inhibit T-cell responses and promote TRegs

Jitschin, Regina ; Braun, Martina ; Büttner, Maike ; Dettmer, Katja ; Bricks, Juliane ; Berger, Jana ; Eckart, Michael J. ; Krause, Stefan W ; Oefner, Peter ; Le Blanc, Katarina ; Mackensen, Andreas ; Mougiakakos, Dimitrios



Abstract

Myeloid derived suppressor cells (MDSCs) represent a heterogeneous population that shares certain characteristics including an aberrant myeloid phenotype and the ability to suppress T-cells. MDSCs have been predominantly studied in malignant diseases and findings suggest involvement in tumor-associated immune suppression. Chronic lymphocytic leukemia (CLL) is the leukemia with the highest ...

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