Dominant Rio1 kinase/ATPase catalytic mutant induces trapping of late pre-40S biogenesis factors in 80S-like ribosomes

URN to cite this document:: urn:nbn:de:bvb:355-epub-305048
DOI to cite this document:: 10.5283/epub.30504

Ferreira-Cerca, Sébastien

; Kiburu, Irene ; Thomson, Emma ; LaRonde, Nicole ; Hurt, Ed

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Date of publication of this fulltext: 30 Jul 2014 08:18

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Abstract

During eukaryotic ribosome biogenesis, members of the conserved atypical serine/threonine protein kinase family, the RIO kinases (Rio1, Rio2 and Rio3) function in small ribosomal subunit biogenesis. Structural analysis of Rio2 indicated a role as a conformation-sensing ATPase rather than a kinase to regulate its dynamic association with the pre-40S subunit. However, it remained elusive at which ...