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Dominant Rio1 kinase/ATPase catalytic mutant induces trapping of late pre-40S biogenesis factors in 80S-like ribosomes

Ferreira-Cerca, Sébastien, Kiburu, Irene, Thomson, Emma, LaRonde, Nicole and Hurt, Ed (2014) Dominant Rio1 kinase/ATPase catalytic mutant induces trapping of late pre-40S biogenesis factors in 80S-like ribosomes. Nucleic Acids Research 2014.

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Date of publication of this fulltext: 30 Jul 2014 08:18

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Other URL: http://nar.oxfordjournals.org/content/early/2014/06/19/nar.gku542.long


Abstract

During eukaryotic ribosome biogenesis, members of the conserved atypical serine/threonine protein kinase family, the RIO kinases (Rio1, Rio2 and Rio3) function in small ribosomal subunit biogenesis. Structural analysis of Rio2 indicated a role as a conformation-sensing ATPase rather than a kinase to regulate its dynamic association with the pre-40S subunit. However, it remained elusive at which ...

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Item type:Article
Date:19 June 2014
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III > House of the Ribosome
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1093/nar/gku542DOI
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:30504
Owner only: item control page

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