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Considering unknown unknowns: reconstruction of nonconfoundable causal relations in biological networks.

Sadeh, Mohammad Javad ; Moffa, Giusi ; Spang, Rainer


Our current understanding of cellular networks is rather incomplete. We over look important but so far unknown genes and mechanisms in the pathways. Moreover, we often only have a partial account of the molecular interactions and modifications of the known players. When analyzing the cell, we look through narrow windows leaving potentially important events in blind spots. Network reconstruction ...


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