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Considering unknown unknowns: reconstruction of nonconfoundable causal relations in biological networks.

Sadeh, Mohammad Javad, Moffa, Giusi and Spang, Rainer (2013) Considering unknown unknowns: reconstruction of nonconfoundable causal relations in biological networks. Journal of computational biology 20 (11), pp. 920-932.

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Abstract

Our current understanding of cellular networks is rather incomplete. We over look important but so far unknown genes and mechanisms in the pathways. Moreover, we often only have a partial account of the molecular interactions and modifications of the known players. When analyzing the cell, we look through narrow windows leaving potentially important events in blind spots. Network reconstruction ...

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Item type:Article
Date:November 2013
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Identification Number:
ValueType
24195708PubMed ID
10.1089/cmb.2013.0119DOI
Classification:
NotationType
AlgorithmsMESH
AnimalsMESH
Bayes TheoremMESH
Cell DifferentiationMESH
Cell ProliferationMESH
Computer SimulationMESH
Embryonic Stem Cells/physiologyMESH
Gene Expression RegulationMESH
Gene Regulatory NetworksMESH
MiceMESH
Models, GeneticMESH
Signal TransductionMESH
Transcription Factors/geneticsMESH
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:30521
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