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Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells

Voloshanenko, Oksana, Erdmann, Gerrit, Dubash, Taronish D, Augustin, Iris, Metzig, Marie, Moffa, Giusi, Hundsrucker, Christian, Kerr, Grainne, Sandmann, Thomas, Anchang, Benedikt, Demir, Kubilay, Boehm, Christina, Leible, Svenja, Ball, Claudia R, Glimm, Hanno, Spang, Rainer and Boutros, Michael (2013) Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells. Nature communications 4, p. 2610.

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Date of publication of this fulltext: 05 Aug 2014 09:29

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Abstract

Aberrant regulation of the Wnt/β-catenin pathway has an important role during the onset and progression of colorectal cancer, with over 90% of cases of sporadic colon cancer featuring mutations in APC or β-catenin. However, it has remained a point of controversy whether these mutations are sufficient to activate the pathway or require additional upstream signals. Here we show that colorectal ...

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Item type:Article
Date:28 October 2013
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Identification Number:
ValueType
11021815PubMed ID
10.1038/ncomms3610DOI
Classification:
NotationType
Adenocarcinoma/pathologyMESH
Adenomatous Polyposis Coli Protein/metabolismMESH
AnimalsMESH
Cell Line, TumorMESH
Cell ProliferationMESH
Colon/pathologyMESH
Colonic Neoplasms/pathologyMESH
Gene Expression Regulation, NeoplasticMESH
HumansMESH
Intracellular Signaling Peptides and Proteins/metabolismMESH
MiceMESH
Mice, Inbred NODMESH
MutationMESH
Neoplasm TransplantationMESH
Receptor, EphB2/metabolismMESH
Receptors, G-Protein-Coupled/metabolismMESH
Signal TransductionMESH
Wnt3 Protein/metabolismMESH
beta Catenin/metabolismMESH
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:30529
Owner only: item control page

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