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Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells

URN to cite this document:
urn:nbn:de:bvb:355-epub-305292
Voloshanenko, Oksana ; Erdmann, Gerrit ; Dubash, Taronish D ; Augustin, Iris ; Metzig, Marie ; Moffa, Giusi ; Hundsrucker, Christian ; Kerr, Grainne ; Sandmann, Thomas ; Anchang, Benedikt ; Demir, Kubilay ; Boehm, Christina ; Leible, Svenja ; Ball, Claudia R ; Glimm, Hanno ; Spang, Rainer ; Boutros, Michael
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Date of publication of this fulltext: 05 Aug 2014 09:29


Abstract

Aberrant regulation of the Wnt/β-catenin pathway has an important role during the onset and progression of colorectal cancer, with over 90% of cases of sporadic colon cancer featuring mutations in APC or β-catenin. However, it has remained a point of controversy whether these mutations are sufficient to activate the pathway or require additional upstream signals. Here we show that colorectal ...

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