Go to content
UR Home

Osteoarthritic cartilage explants affect extracellular matrix production and composition in cocultured bone marrow-derived mesenchymal stem cells and articular chondrocytes

Lehy, Michaela, Seitz, Andreas, Dürselen, Lutz, Springorum, Hans-Robert, Angele, Peter, Ignatius, Anita, Grifka, Joachim and Grässel, Susanne (2014) Osteoarthritic cartilage explants affect extracellular matrix production and composition in cocultured bone marrow-derived mesenchymal stem cells and articular chondrocytes. Stem Cell Research & therapy 5 (3).

[img]
Preview
License: Creative Commons Attribution 3.0
PDF
Download (3MB)
Date of publication of this fulltext: 04 Aug 2014 08:31

at publisher (via DOI)


Abstract

Introduction In the present study, we established a novel in vitro coculture model to evaluate the influence of osteoarthritis (OA) cartilage explants on the composition of newly produced matrix and chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells (BMSCs) and the phenotype of OA chondrocytes. In addition, we included a “tri-culture” model, whereby a mixture of ...

plus


Export bibliographical data



Item type:Article
Date:10 June 2014
Institutions:Medicine > Lehrstuhl für Orthopädie
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1186/scrt466DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:30546
Owner only: item control page

Downloads

Downloads per month over past year

  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons