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Osteoarthritic cartilage explants affect extracellular matrix production and composition in cocultured bone marrow-derived mesenchymal stem cells and articular chondrocytes

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Lehy, Michaela ; Seitz, Andreas ; Dürselen, Lutz ; Springorum, Hans-Robert ; Angele, Peter ; Ignatius, Anita ; Grifka, Joachim ; Grässel, Susanne
Date of publication of this fulltext: 04 Aug 2014 08:31


Introduction In the present study, we established a novel in vitro coculture model to evaluate the influence of osteoarthritis (OA) cartilage explants on the composition of newly produced matrix and chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells (BMSCs) and the phenotype of OA chondrocytes. In addition, we included a “tri-culture” model, whereby a mixture of ...


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