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Melanoma inhibitory activity promotes melanoma development through activation of YBX1

Schmid, Rainer, Meyer, Katharina, Spang, Rainer, Schittek, Birgit and Bosserhoff, Anja-Katrin (2013) Melanoma inhibitory activity promotes melanoma development through activation of YBX1. Pigment cell & melanoma research 26 (5), pp. 685-696.

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Abstract

Melanoma inhibitory activity (MIA), a small soluble secreted protein, is functionally important for progression of malignant melanoma. We recently revealed that p54(nrb) acts as a mediator of MIA action. In this study, we characterize the transcriptional regulation of p54(nrb) by MIA to explain MIA's molecular action. We identified one highly conserved region in the p54(nrb) promoter that is ...

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Item type:Article
Date:September 2013
Institutions:Medicine > Lehrstuhl für Pathologie
Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Identification Number:
ValueType
23672612PubMed ID
10.1111/pcmr.12119DOI
Classification:
NotationType
AnimalsMESH
Base Pairing/geneticsMESH
Base SequenceMESH
Binding SitesMESH
Binding, CompetitiveMESH
Carcinogenesis/pathologyMESH
Conserved Sequence/geneticsMESH
Disease ProgressionMESH
Electrophoretic Mobility Shift AssayMESH
Extracellular Matrix Proteins/metabolismMESH
Gene Expression Regulation, NeoplasticMESH
HumansMESH
Melanoma/pathologyMESH
MiceMESH
Molecular Sequence DataMESH
Mutation/geneticsMESH
Neoplasm Proteins/metabolismMESH
Nuclear Matrix-Associated Proteins/geneticsMESH
Octamer Transcription Factors/geneticsMESH
Promoter Regions, GeneticMESH
Protein Binding/geneticsMESH
RNA-Binding Proteins/geneticsMESH
Skin Neoplasms/pathologyMESH
Y-Box-Binding Protein 1/metabolismMESH
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:30561
Owner only: item control page
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