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Melanoma inhibitory activity promotes melanoma development through activation of YBX1

Schmid, Rainer ; Meyer, Katharina ; Spang, Rainer ; Schittek, Birgit ; Bosserhoff, Anja-Katrin



Abstract

Melanoma inhibitory activity (MIA), a small soluble secreted protein, is functionally important for progression of malignant melanoma. We recently revealed that p54(nrb) acts as a mediator of MIA action. In this study, we characterize the transcriptional regulation of p54(nrb) by MIA to explain MIA's molecular action. We identified one highly conserved region in the p54(nrb) promoter that is ...

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