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Aberrant lymphocyte enhancer-binding factor 1 expression is characteristic for sporadic Burkitt's lymphoma

Walther, Neele ; Ulrich, Antje ; Vockerodt, Martina ; von Bonin, Frederike ; Klapper, Wolfram ; Meyer, Katharina ; Eberth, Sonja ; Pukrop, Tobias ; Spang, Rainer ; Trümper, Lorenz ; Kube, Dieter



Abstract

Burkitt's lymphoma (BL) is a highly malignant, aggressive non-Hodgkin's lymphoma derived from germinal center B cells. Recently, global gene expression profiling of patient samples led to a molecular definition of BL with lymphocyte enhancer-binding factor 1 (LEF1) as a signature gene. Herein, we report the expression of nucleic LEF1 in 15 of 18 patients with BL and the identification of LEF1 ...

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