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Biological characterization of adult MYC-translocation-positive mature B-cell lymphomas other than molecular Burkitt lymphoma

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Aukema, Sietse M. ; Kreuz, Markus ; Kohler, Christian ; Rosolowski, Maciej ; Hasenclever, Dirk ; Hummel, Michael ; Küppers, Ralf ; Lenze, Dido ; Ott, German ; Pott, Christiane ; Richter, Julia ; Rosenwald, Andreas ; Szczepanowski, Monika ; Schwaenen, Carsten ; Stein, Harald ; Trautmann, Heiko ; Wessendorf, Swen ; Trümper, Lorenz ; Loeffler, Markus ; Spang, Rainer ; Kluin, Philip M. ; Klapper, Wolfram ; Siebert, Reiner
License: Creative Commons Attribution 3.0
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Date of publication of this fulltext: 07 Aug 2014 14:06


Chromosomal translocations affecting the MYC oncogene are the biological hallmark of Burkitt lymphomas but also occur in a subset of other mature B-cell lymphomas. If accompanied by a chromosomal break targeting the BCL2 and/or BCL6 oncogene these MYC translocation-positive (MYC(+)) lymphomas are called double-hit lymphomas, otherwise the term single-hit lymphomas is applied. In order to ...


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