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Definition of genetic events directing the development of distinct types of brain tumors from postnatal neural stem/progenitor cells

Hertwig, Falk ; Meyer, Katharina ; Braun, Sebastian ; Ek, Sara ; Spang, Rainer ; Pfenninger, Cosima V. ; Artner, Isabella ; Prost, Gaëlle ; Chen, Xinbin ; Biegel, Jaclyn A. ; Judkins, Alexander R. ; Englund, Elisabet ; Nuber, Ulrike A.


Although brain tumors are classified and treated based upon their histology, the molecular factors involved in the development of various tumor types remain unknown. In this study, we show that the type and order of genetic events directs the development of gliomas, central nervous system primitive neuroectodermal tumors, and atypical teratoid/rhabdoid-like tumors from postnatal mouse neural ...


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