Go to content
UR Home

Targeting melanoma metastasis and immunosuppression with a new mode of melanoma inhibitory activity (MIA) protein inhibition

Schmidt, Jennifer, Riechers, Alexander, Stoll, Raphael, Amann, Thomas, Fink, Florian, Spruss, Thilo, Gronwald, Wolfram, König, Burkhard, Hellerbrand, Claus and Bosserhoff, Anja Katrin (2012) Targeting melanoma metastasis and immunosuppression with a new mode of melanoma inhibitory activity (MIA) protein inhibition. PloS ONE 7 (5), e37941.

[img]
Preview
License: Creative Commons Attribution 3.0
PDF - Published Version
Download (1MB)
Date of publication of this fulltext: 11 Aug 2014 10:17

at PubMed

at publisher (via DOI)


Abstract

Melanoma is the most aggressive form of skin cancer, with fast progression and early dissemination mediated by the melanoma inhibitory activity (MIA) protein. Here, we discovered that dimerization of MIA is required for functional activity through mutagenesis of MIA which showed the correlation between dimerization and functional activity. We subsequently identified the dodecapeptide AR71, which ...

plus


Export bibliographical data



Item type:Article
Date:2012
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
22666418PubMed ID
10.1371/journal.pone.0037941DOI
Classification:
NotationType
Amino Acid SequenceMESH
AnimalsMESH
Antineoplastic Agents/therapeutic useMESH
Cell Line, TumorMESH
Extracellular Matrix Proteins/metabolismMESH
HumansMESH
Immune Tolerance/drug effectsMESH
Melanoma/pathologyMESH
Melanoma, Experimental/pathologyMESH
MiceMESH
Models, MolecularMESH
Molecular Sequence DataMESH
Molecular Targeted Therapy/methodsMESH
Neoplasm MetastasisMESH
Neoplasm Proteins/metabolismMESH
Oligopeptides/therapeutic useMESH
Protein Multimerization/drug effectsMESH
Protein Structure, QuaternaryMESH
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:30591
Owner only: item control page

Downloads

Downloads per month over past year

  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons