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Targeting melanoma metastasis and immunosuppression with a new mode of melanoma inhibitory activity (MIA) protein inhibition

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Schmidt, Jennifer ; Riechers, Alexander ; Stoll, Raphael ; Amann, Thomas ; Fink, Florian ; Spruss, Thilo ; Gronwald, Wolfram ; König, Burkhard ; Hellerbrand, Claus ; Bosserhoff, Anja Katrin
License: Creative Commons: Attribution 3.0
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Date of publication of this fulltext: 11 Aug 2014 10:17


Melanoma is the most aggressive form of skin cancer, with fast progression and early dissemination mediated by the melanoma inhibitory activity (MIA) protein. Here, we discovered that dimerization of MIA is required for functional activity through mutagenesis of MIA which showed the correlation between dimerization and functional activity. We subsequently identified the dodecapeptide AR71, which ...


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