Targeting melanoma metastasis and immunosuppression with a new mode of melanoma inhibitory activity (MIA) protein inhibition

URN to cite this document:: urn:nbn:de:bvb:355-epub-305916
DOI to cite this document:: 10.5283/epub.30591

Schmidt, Jennifer ; Riechers, Alexander ; Stoll, Raphael ; Amann, Thomas ; Fink, Florian ; Spruss, Thilo ; Gronwald, Wolfram ; König, Burkhard ; Hellerbrand, Claus ; Bosserhoff, Anja Katrin

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Date of publication of this fulltext: 11 Aug 2014 10:17

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Abstract

Melanoma is the most aggressive form of skin cancer, with fast progression and early dissemination mediated by the melanoma inhibitory activity (MIA) protein. Here, we discovered that dimerization of MIA is required for functional activity through mutagenesis of MIA which showed the correlation between dimerization and functional activity. We subsequently identified the dodecapeptide AR71, which ...