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High Myc activity is an independent negative prognostic factor for diffuse large B cell lymphomas

Schrader, Alexandra ; Bentink, Stefan ; Spang, Rainer ; Lenze, Dido ; Hummel, Michael ; Kuo, Michael ; Arrand, John R ; Murray, Paul G ; Trümper, Lorenz ; Kube, Dieter ; Vockerodt, Martina



Abstract

Gene expression profiling has recently enabled the reclassification of aggressive non-Hodgkin lymphomas (aNHL) into distinct subgroups. In Burkitt lymphoma (BL) aberrant c-Myc activity results from IG-MYC translocations. However, MYC aberrations are not limited to BLs and then have a negative prognostic impact. In this study, we investigated to which extent aberrant c-Myc activity plays a ...

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