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Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing

Richter, Julia ; Schlesner, Matthias ; Hoffmann, Steve ; Kreuz, Markus ; Leich, Ellen ; Burkhardt, Birgit ; Rosolowski, Maciej ; Ammerpohl, Ole ; Wagener, Rabea ; Bernhart, Stephan H. ; Lenze, Dido ; Szczepanowski, Monika ; Paulsen, Maren ; Lipinski, Simone ; Russell, Robert B. ; Adam-Klages, Sabine ; Apic, Gordana ; Claviez, Alexander ; Hasenclever, Dirk ; Hovestadt, Volker ; Hornig, Nadine ; Korbel, Jan O ; Kube, Dieter ; Langenberger, David ; Lawerenz, Chris ; Lisfeld, Jasmin ; Meyer, Katharina ; Picelli, Simone ; Pischimarov, Jordan ; Radlwimmer, Bernhard ; Rausch, Tobias ; Rohde, Marius ; Schilhabel, Markus ; Scholtysik, René ; Spang, Rainer ; Trautmann, Heiko ; Zenz, Thorsten ; Borkhardt, Arndt ; Drexler, Hans G. ; Möller, Peter ; MacLeod, Roderick A. F. ; Pott, Christiane ; Schreiber, Stefan ; Trümper, Lorenz ; Loeffler, Markus ; Stadler, Peter F. ; Lichter, Peter ; Eils, Roland ; Küppers, Ralf ; Hummel, Michael ; Klapper, Wolfram ; Rosenstiel, Philip ; Rosenwald, Andreas ; Brors, Benedikt ; Siebert, Reiner



Abstract

Burkitt lymphoma is a mature aggressive B-cell lymphoma derived from germinal center B cells. Its cytogenetic hallmark is the Burkitt translocation t(8;14)(q24;q32) and its variants, which juxtapose the MYC oncogene with one of the three immunoglobulin loci. Consequently, MYC is deregulated, resulting in massive perturbation of gene expression. Nevertheless, MYC deregulation alone seems not to be ...

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