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CALM/AF10-positive leukemias show upregulation of genes involved in chromatin assembly and DNA repair processes and of genes adjacent to the breakpoint at 10p12

Mulaw, M. A., Krause, A., Krause, A. J., Deshpande, A. J., Krause, L. F., Rouhi, A., La Starza, R., Borkhardt, A., Buske, C., Mecucci, C., Ludwig, W.-D., Lottaz, Claudio and Bohlander, S. K. (2012) CALM/AF10-positive leukemias show upregulation of genes involved in chromatin assembly and DNA repair processes and of genes adjacent to the breakpoint at 10p12. Leukemia 26 (5), pp. 1012-1019.

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Abstract

The t(10;11)(p12;q14) is a recurring chromosomal translocation that gives rise to the CALM/AF10 fusion gene, which is found in acute myeloid leukemia, acute lymphoblastic leukemia and malignant lymphoma. We analyzed the fusion transcripts in 20 new cases of CALM/AF10-positive leukemias, and compared the gene expression profile of 10 of these to 125 patients with other types of leukemia and 10 ...

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Item type:Article
Date:May 2012
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Identification Number:
ValueType
22064352PubMed ID
10.1038/leu.2011.307DOI
Classification:
NotationType
AnimalsMESH
Chromatin Assembly and Disassembly/geneticsMESH
Chromosome Fragile SitesMESH
Chromosomes, Human, Pair 10MESH
DNA Repair/geneticsMESH
HumansMESH
Leukemia/geneticsMESH
MiceMESH
Monomeric Clathrin Assembly Proteins/geneticsMESH
Reverse Transcriptase Polymerase Chain ReactionMESH
Transcription Factors/geneticsMESH
Translocation, GeneticMESH
Up-RegulationMESH
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:30606
Owner only: item control page
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