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CALM/AF10-positive leukemias show upregulation of genes involved in chromatin assembly and DNA repair processes and of genes adjacent to the breakpoint at 10p12

Mulaw, M. A. ; Krause, A. ; Krause, A. J. ; Deshpande, A. J. ; Krause, L. F. ; Rouhi, A. ; La Starza, R. ; Borkhardt, A. ; Buske, C. ; Mecucci, C. ; Ludwig, W.-D. ; Lottaz, Claudio ; Bohlander, S. K.



Abstract

The t(10;11)(p12;q14) is a recurring chromosomal translocation that gives rise to the CALM/AF10 fusion gene, which is found in acute myeloid leukemia, acute lymphoblastic leukemia and malignant lymphoma. We analyzed the fusion transcripts in 20 new cases of CALM/AF10-positive leukemias, and compared the gene expression profile of 10 of these to 125 patients with other types of leukemia and 10 ...

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