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Down-regulation of methylthioadenosine phosphorylase (MTAP) induces progression of hepatocellular carcinoma via accumulation of 5'-deoxy-5'-methylthioadenosine (MTA)

Kirovski, Georgi ; Stevens, Axel Peter ; Czech, Barbara ; Dettmer, Katja ; Weiss, Thomas S. ; Wild, Peter ; Hartmann, Arndt ; Bosserhoff, Anja-Katrin ; Oefner, Peter J. ; Hellerbrand, Claus



Abstract

Recently, we have shown that down-regulation of methylthioadenosine phosphorylase (MTAP) in hepatocellular carcinoma (HCC) cells enhances the invasive potential and the resistance against cytokines. Here, we aimed at investigating the molecular mechanism underlying this tumor-promoting effect and expanded the analysis to a large series of human HCC tissues. Liquid chromatography tandem mass ...

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