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Down-regulation of methylthioadenosine phosphorylase (MTAP) induces progression of hepatocellular carcinoma via accumulation of 5'-deoxy-5'-methylthioadenosine (MTA)

Kirovski, Georgi, Stevens, Axel Peter, Czech, Barbara, Dettmer, Katja, Weiss, Thomas S., Wild, Peter, Hartmann, Arndt, Bosserhoff, Anja-Katrin, Oefner, Peter J. and Hellerbrand, Claus (2011) Down-regulation of methylthioadenosine phosphorylase (MTAP) induces progression of hepatocellular carcinoma via accumulation of 5'-deoxy-5'-methylthioadenosine (MTA). The American journal of pathology 178 (3), pp. 1145-1152.

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Abstract

Recently, we have shown that down-regulation of methylthioadenosine phosphorylase (MTAP) in hepatocellular carcinoma (HCC) cells enhances the invasive potential and the resistance against cytokines. Here, we aimed at investigating the molecular mechanism underlying this tumor-promoting effect and expanded the analysis to a large series of human HCC tissues. Liquid chromatography tandem mass ...

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Item type:Article
Date:March 2011
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Medicine > Lehrstuhl für Innere Medizin I
Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
21356366PubMed ID
10.1016/j.ajpath.2010.11.059DOI
Classification:
NotationType
AgedMESH
Carcinoma, Hepatocellular/pathologyMESH
Cell Line, TumorMESH
Deoxyadenosines/pharmacologyMESH
Disease ProgressionMESH
Down-Regulation/drug effectsMESH
FemaleMESH
Gene Expression Regulation, Neoplastic/drug effectsMESH
Hepatic Stellate Cells/enzymologyMESH
HumansMESH
Liver Neoplasms/pathologyMESH
MaleMESH
Middle AgedMESH
NF-kappa B/metabolismMESH
Purine-Nucleoside Phosphorylase/metabolismMESH
RNA, Messenger/metabolismMESH
Thionucleosides/pharmacologyMESH
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:30612
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