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Translocations activating IRF4 identify a subtype of germinal center-derived B-cell lymphoma affecting predominantly children and young adults

Salaverria, Itziar ; Philipp, Claudia ; Oschlies, Ilske ; Kohler, Christian ; Kreuz, Markus ; Szczepanowski, Monika ; Burkhardt, Birgit ; Trautmann, Heiko ; Gesk, Stefan ; Andrusiewicz, Miroslaw ; Berger, Hilmar ; Fey, Miriam ; Harder, Lana ; Hasenclever, Dirk ; Hummel, Michael ; Loeffler, Markus ; Mahn, Friederike ; Martin-Guerrero, Idoia ; Pellissery, Shoji ; Pott, Christiane ; Pfreundschuh, Michael ; Reiter, Alfred ; Richter, Julia ; Rosolowski, Maciej ; Schwaenen, Carsten ; Stein, Harald ; Trümper, Lorenz ; Wessendorf, Swen ; Spang, Rainer ; Küppers, Ralf ; Klapper, Wolfram ; Siebert, Reiner



Abstract

The prognosis of germinal center-derived B-cell (GCB) lymphomas, including follicular lymphoma and diffuse large-B-cell lymphoma (DLBCL), strongly depends on age. Children have a more favorable outcome than adults. It is not known whether this is because of differences in host characteristics, treatment protocols, or tumor biology, including the presence of chromosomal alterations. By screening ...

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