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Comparison of gene expression profiles between human and mouse monocyte subsets

Ingersoll, Molly A. ; Spanbroek, Rainer ; Lottaz, Claudio ; Gautier, Emmanuel L. ; Frankenberger, Marion ; Hoffmann, Reinhard ; Lang, Roland ; Haniffa, Muzlifah ; Collin, Matthew ; Tacke, Frank ; Habenicht, Andreas .J R. ; Ziegler-Heitbrock, Loems ; Randolph, Gwendalyn J.



Abstract

Blood of both humans and mice contains 2 main monocyte subsets. Here, we investigated the extent of their similarity using a microarray approach. Approximately 270 genes in humans and 550 genes in mice were differentially expressed between subsets by 2-fold or more. More than 130 of these gene expression differences were conserved between mouse and human monocyte subsets. We confirmed numerous of ...

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