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Comparison of gene expression profiles between human and mouse monocyte subsets

Ingersoll, Molly A., Spanbroek, Rainer, Lottaz, Claudio, Gautier, Emmanuel L., Frankenberger, Marion, Hoffmann, Reinhard, Lang, Roland, Haniffa, Muzlifah, Collin, Matthew, Tacke, Frank, Habenicht, Andreas .J R., Ziegler-Heitbrock, Loems and Randolph, Gwendalyn J. (2010) Comparison of gene expression profiles between human and mouse monocyte subsets. Blood 115 (3), e10-e19.

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Abstract

Blood of both humans and mice contains 2 main monocyte subsets. Here, we investigated the extent of their similarity using a microarray approach. Approximately 270 genes in humans and 550 genes in mice were differentially expressed between subsets by 2-fold or more. More than 130 of these gene expression differences were conserved between mouse and human monocyte subsets. We confirmed numerous of ...

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Item type:Article
Date:January 2010
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Identification Number:
ValueType
19965649PubMed ID
10.1182/blood-2009-07-235028DOI
Classification:
NotationType
AnimalsMESH
Cells, CulturedMESH
Gene Expression ProfilingMESH
HumansMESH
MaleMESH
MiceMESH
Mice, Inbred C57BLMESH
Monocytes/metabolismMESH
Oligonucleotide Array Sequence AnalysisMESH
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:30629
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