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Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein

Hundsrucker, Christian ; Skroblin, Philipp ; Christian, Frank ; Zenn, Hans-Michael ; Popara, Viola ; Joshi, Mangesh ; Eichhorst, Jenny ; Wiesner, Burkhard ; Herberg, Friedrich W. ; Reif, Bernd ; Rosenthal, Walter ; Klussmann, Enno



Abstract

A-kinase anchoring proteins (AKAPs) include a family of scaffolding proteins that target protein kinase A (PKA) and other signaling proteins to cellular compartments and thereby confine the activities of the associated proteins to distinct regions within cells. AKAPs bind PKA directly. The interaction is mediated by the dimerization and docking domain of regulatory subunits of PKA and the ...

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