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Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein

Hundsrucker, Christian, Skroblin, Philipp, Christian, Frank, Zenn, Hans-Michael, Popara, Viola, Joshi, Mangesh, Eichhorst, Jenny, Wiesner, Burkhard, Herberg, Friedrich W, Reif, Bernd, Rosenthal, Walter and Klussmann, Enno (2010) Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein. The Journal of biological chemistry 285 (8), pp. 5507-5521.

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Abstract

A-kinase anchoring proteins (AKAPs) include a family of scaffolding proteins that target protein kinase A (PKA) and other signaling proteins to cellular compartments and thereby confine the activities of the associated proteins to distinct regions within cells. AKAPs bind PKA directly. The interaction is mediated by the dimerization and docking domain of regulatory subunits of PKA and the ...

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Item type:Article
Date:February 2010
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Identification Number:
ValueType
20007971PubMed ID
10.1074/jbc.M109.047944DOI
Classification:
NotationType
A Kinase Anchor Proteins/metabolismMESH
Amino Acid Motifs/physiologyMESH
Cell Line, TumorMESH
Cyclic AMP-Dependent Protein Kinases/metabolismMESH
Glycogen Synthase Kinase 3/metabolismMESH
HumansMESH
Protein Binding/physiologyMESH
Protein Multimerization/physiologyMESH
Protein Structure, Tertiary/physiologyMESH
Signal Transduction/physiologyMESH
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:30633
Owner only: item control page
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