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Comparison of derivatization and chromatographic methods for GC-MS analysis of amino acid enantiomers in physiological samples

Waldhier, Magdalena Ch., Dettmer, Katja, Gruber, Michael and Oefner, Peter J. (2010) Comparison of derivatization and chromatographic methods for GC-MS analysis of amino acid enantiomers in physiological samples. Journal of chromatography B 878 (15-16), pp. 1103-1112.

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Abstract

GC-MS analysis of fluorinated and non-fluorinated chloroformate and anhydride derivatives of amino acid (AA) enantiomers on two different chiral columns was compared for the direct quantification of free L- and D-AAs in human serum and urine in a single analytical run. Best sensitivity was achieved with pentafluoropropionic anhydride/heptafluorobutanol derivatives separated on a Chirasil-L-Val ...

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Item type:Article
Date:May 2010
Institutions:Medicine > Lehrstuhl für Anästhesiologie
Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
20371216PubMed ID
10.1016/j.jchromb.2010.03.021DOI
Classification:
NotationType
Amino Acids/urineMESH
Anhydrides/chemistryMESH
Formates/chemistryMESH
Gas Chromatography-Mass Spectrometry/methodsMESH
HumansMESH
Methanol/chemistryMESH
Renal Insufficiency/metabolismMESH
Sensitivity and SpecificityMESH
Sodium Hydroxide/chemistryMESH
StereoisomerismMESH
TemperatureMESH
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:30639
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