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Expression patterns of the mouse Spir-2 actin nucleator

Pleiser, Sandra ; Rock, Rebecca ; Wellmann, Jutta ; Gessler, Manfred ; Kerkhoff, Eugen



Abstract

Spir proteins are the founding members of the novel class of WH2 domain containing actin nucleation factors. They initiate actin polymerization by binding of actin monomers to four WH2 domains in the central part of the proteins. Despite their ability to nucleate actin polymerization in vitro by themselves, Spir proteins form a regulatory complex with the distinct actin nucleators of the formin ...

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