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New insights into the biology and origin of mature aggressive B-cell lymphomas by combined epigenomic, genomic, and transcriptional profiling

Martín-Subero, José I. ; Kreuz, Markus ; Bibikova, Marina ; Bentink, Stefan ; Ammerpohl, Ole ; Wickham-Garcia, Eliza ; Rosolowski, Maciej ; Richter, Julia ; Lopez-Serra, Lidia ; Ballestar, Esteban ; Berger, Hilmar ; Agirre, Xabier ; Bernd, Heinz-Wolfram ; Calvanese, Vincenzo ; Cogliatti, Sergio B. ; Drexler, Hans G. ; Fan, Jian-Bing ; Fraga, Mario F. ; Hansmann, Martin L. ; Hummel, Michael ; Klapper, Wolfram ; Korn, Bernhard ; Küppers, Ralf ; Macleod, Roderick A. F. ; Möller, Peter ; Ott, German ; Pott, Christiane ; Prosper, Felipe ; Rosenwald, Andreas ; Schwaenen, Carsten ; Schübeler, Dirk ; Seifert, Marc ; Stürzenhofecker, Benjamin ; Weber, Michael ; Wessendorf, Swen ; Loeffler, Markus ; Trümper, Lorenz ; Stein, Harald ; Spang, Rainer ; Esteller, Manel ; Barker, David ; Hasenclever, Dirk ; Siebert, Reiner



Abstract

Lymphomas are assumed to originate at different stages of lymphocyte development through chromosomal aberrations. Thus, different lymphomas resemble lymphocytes at distinct differentiation stages and show characteristic morphologic, genetic, and transcriptional features. Here, we have performed a microarray-based DNA methylation profiling of 83 mature aggressive B-cell non-Hodgkin lymphomas ...

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