; Klapper, Wolfram ; Kreuz, Markus ; Lenze, Dido ; Loeffler, Markus ; Möller, Peter ; Müller-Hermelink, Hans-Konrad ; Ott, German ; Rosolowski, Maciej ; Rosenwald, Andreas ; Ruf, Sandra ; Siebert, Reiner ; Spang, Rainer ; Stein, Harald ; Truemper, Lorenz ; Lichter, Peter ; Bentz, Martin ; Wessendorf, Swen | Item type: | Article | ||||||||||||||||||||||||||||||||||||
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| Journal or Publication Title: | Genes, Chromosomes and Cancer | ||||||||||||||||||||||||||||||||||||
| Publisher: | WILEY | ||||||||||||||||||||||||||||||||||||
| Place of Publication: | HOBOKEN | ||||||||||||||||||||||||||||||||||||
| Volume: | 48 | ||||||||||||||||||||||||||||||||||||
| Number of Issue or Book Chapter: | 1 | ||||||||||||||||||||||||||||||||||||
| Page Range: | pp. 39-54 | ||||||||||||||||||||||||||||||||||||
| Date: | January 2009 | ||||||||||||||||||||||||||||||||||||
| Institutions: | Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang) Informatics and Data Science > Department Computational Life Science > Lehrstuhl für Statistische Bioinformatik (Prof. Spang) | ||||||||||||||||||||||||||||||||||||
| Identification Number: |
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| Classification: |
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| Keywords: | B-CELL LYMPHOMA; DNA COPY NUMBER; CHRONIC LYMPHOCYTIC-LEUKEMIA; MOLECULAR CHARACTERIZATION; CHROMOSOMAL-ABNORMALITIES; MALIGNANT-LYMPHOMA; PROGNOSTIC FACTORS; CONSENSUS REGIONS; BURKITTS-LYMPHOMA; HYBRIDIZATION; | ||||||||||||||||||||||||||||||||||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine 600 Technology > 610 Medical sciences Medicine | ||||||||||||||||||||||||||||||||||||
| Status: | Published | ||||||||||||||||||||||||||||||||||||
| Refereed: | Yes, this version has been refereed | ||||||||||||||||||||||||||||||||||||
| Created at the University of Regensburg: | Partially | ||||||||||||||||||||||||||||||||||||
| Item ID: | 30656 |
Abstract
Follicular lymphoma (FL) is characterized by a large number of chromosomal aberrations. However, their exact genomic extension and involved target genes remain to be determined. For this purpose, we used array-based intermediate-high resolution genomic profiling in combination with Affymetrix (TM) gene expression analysis. Tumor specimens from 128 FL patients were analyzed for the presence of ...

Abstract
Follicular lymphoma (FL) is characterized by a large number of chromosomal aberrations. However, their exact genomic extension and involved target genes remain to be determined. For this purpose, we used array-based intermediate-high resolution genomic profiling in combination with Affymetrix (TM) gene expression analysis. Tumor specimens from 128 FL patients were analyzed for the presence of genomic aberrations and the results were correlated to clinical data sets and mRNA expression levels. In 114 (89%) of the 128 analyzed cases, a total of 688 genomic aberrations (384 gains/amplifications and 304 losses) were detected. Frequent genomic aberrations were: - 1p36 (18%), +2p15 (24%), -3q (14%), -6q (25%), +7p (19%), +7q (23%), +8q (14%), -9p (16%), - 11q (15%), +12q (20%), -13q (11%), -17p (16%), +18p (18%), and +18q (28%). Critical segments of these imbalances were delineated to genomic fragments with a minimum size down to 0.2 Mb. By comparison of these with mRNA gene expression data, putative candidate genes were identified. Moreover, we found that deletions affecting the tumor suppressor gene CDKN2A/B on 9p21 were detected in nontransformed FL grade I-II. For this aberration as well as for -6q25 and -6q26, an association with inferior survival was observed. (C) 2008 Wiley-Liss, Inc.
Metadata last modified: 29 Sep 2021 07:40
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