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Microarray-based genomic profiling reveals novel genomic aberrations in follicular lymphoma which associate with patient survival and gene expression status

Schwaenen, Carsten ; Viardot, Andreas ; Berger, Hilmar ; Barth, Thomas F. E. ; Bentink, Stefa ; Döhner, Hartmut ; Enz, Martina ; Feller, Alfred C. ; Hansmann, Martin-Leo ; Hummel, Michael ; Kestler, Hans A ; Klapper, Wolfram ; Kreuz, Markus ; Lenze, Dido ; Loeffler, Markus ; Möller, Peter ; Müller-Hermelink, Hans-Konrad ; Ott, German ; Rosolowski, Maciej ; Rosenwald, Andreas ; Ruf, Sandra ; Siebert, Reiner ; Spang, Rainer ; Stein, Harald ; Truemper, Lorenz ; Lichter, Peter ; Bentz, Martin ; Wessendorf, Swen



Abstract

Follicular lymphoma (FL) is characterized by a large number of chromosomal aberrations. However, their exact genomic extension and involved target genes remain to be determined. For this purpose, we used array-based intermediate-high resolution genomic profiling in combination with Affymetrix gene expression analysis. Tumor specimens from 128 FL patients were analyzed for the presence of genomic ...

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